Absolute vs Logical Path:
This is really a question about whether the path to the Python interpreter should be absolute or Logical (/usr/bin/env) in respect to portability.
Encountering other answers on this and other Stack sites which talked about the issue in a general way without supporting proofs, I've performed some really, REALLY, granular testing & analysis on this very question on the unix.stackexchange.com. Rather than paste that answer here, I'll point those interested to the comparative analysis to that answer:
https://unix.stackexchange.com/a/566019/334294
Being a Linux Engineer, my goal is always to provide the most suitable, optimized hosts for my developer clients, so the issue of Python environments was something I really needed a solid answer to. My view after the testing was that the logical path in the she-bang was the better of the (2) options.