If you have more than one version of Python and the script needs to run under a specific version, the she-bang can ensure the right one is used when the script is executed directly, for example:
#!/usr/bin/python2.7
Note the script could still be run via a complete Python command line, or via import, in which case the she-bang is ignored. But for scripts run directly, this is a decent reason to use the she-bang.
#!/usr/bin/env python is generally the better approach, but this helps with special cases.
Usually it would be better to establish a Python virtual environment, in which case the generic #!/usr/bin/env python would identify the correct instance of Python for the virtualenv.
